Can people become immune to NSAIDs after a certain time?

I was on Arcoxia 60mg for a few weeks and it worked great. I went from bad pain to even out running a bit. The pain then came back and was upped to 90mg which again lasted a couple of months.
I’m wondering if people can be on a certain antiinflammatory for X amount of time, before they become less effective and have to move on to something else – not because the pain is worse, but because the antiinflam has become less effective than it was initially.
My doctor said some people start on one, then move on to others before coming back to the first one again.
Has anybody experienced this or have knowledge of it?
Thanks for the answers, so does it mean wait 90 days without any NSAIDS at all, or simply be on a different one for 90 days before coming back to the original ?
Comments
this is very common. any substance ingested into the body over a period of time, the body grows accustom too. dosage levels must always be raised when this happens and it is a never ending spiral. another tack is to go off the meds. the body will return to its normal state in 90 days. then medications will preform again.
I’m on indocin-a very powerful NSAID. I noticed that some days it doesn’t work as well as others. I think this is simply because your condition is just worse some days. Depends on what your condition is but some days I don’t even need it, some days I do, and some days when I need it it doesn’t seem to work.
I haven’t heard that it gets less effective with time.
Hope this helps.
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